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Biologic therapy for chronic spontaneous urticaria in pediatrics and adolescents: current landscape, challenges, and

Katharina Marlies Duda1, Bettina Wedi1

  • 1Department of Dermatology and Allergy, Comprehensive Allergy Center, Hannover Medical School, Hannover, Germany.

Expert Opinion on Biological Therapy
|May 11, 2024
PubMed

Insights

Biologic therapies show promise for chronic spontaneous urticaria (CSU) in children and adolescents, but more research is needed. Current data on safety and efficacy in young patients are limited, highlighting the need for pediatric-specific studies.

Area of Science:

  • Pediatric immunology
  • Dermatology
  • Pharmacology

Background:

  • Chronic spontaneous urticaria (CSU) significantly impacts pediatric and adolescent well-being.
  • Limited data exist on biologic treatment safety and efficacy in these young populations.

Purpose of the Study:

  • To review current biologic treatments for pediatric and adolescent CSU.
  • To explore the emerging landscape of biologic therapies for this demographic.

Main Methods:

  • Literature review of current biologic treatments for CSU in pediatrics and adolescents.
  • Analysis of existing data on omalizumab, ligelizumab, CT-P39, and dupilumab.
  • Expert opinion synthesis on research gaps and future directions.

Main Results:

  • Omalizumab's delayed CSU approval contrasts with its asthma indication.
  • Ligelizumab and CT-P39 lack pediatric-specific data.
  • Dupilumab shows progress with recent approvals for other conditions in young children.

Conclusions:

  • Scarcity of controlled pediatric CSU trials necessitates comprehensive studies.
  • Age-specific data and collaboration are crucial for expanding treatment indications.
  • The outlook for biologic therapy in pediatric and adolescent CSU is promising, with high prevalence underscoring treatment needs.
Abstract

Keywords:
CT-P39Chronic spontaneous urticariabiologic therapycontrolled trialsdupilumabligelizumabomalizumabpediatric

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