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Updated: Jun 26, 2025
07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
36.2K
Immunity in adipose tissues: Cutting through the fat.
Troy D Randall1, Selene Meza-Perez1
1Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Immunological Reviews
|May 11, 2024
Summary
Adipose tissue plays crucial roles in both metabolism and immunity. This review explores how immune cells within fat tissue interact with metabolic functions, influencing health and disease.
Area of Science:
- Immunology and metabolic research.
- Exploration of adipose tissue's dual role in immune and metabolic functions.
Background:
- Adipose tissue is traditionally known for energy storage and metabolic regulation.
- Emerging evidence highlights significant immune functions within adipose tissues.
Discussion:
- Focus on adipose-resident immune cells, including macrophages, T cells (Tregs), and B1 cells.
- Examination of fat-associated lymphoid structures (FALCs) and their role in local immune responses.
- Discussion of reciprocal interactions between immune cells and adipocytes, impacting both immune and metabolic health.
Key Insights:
- Obesity and metabolic status profoundly affect adipose-resident macrophage phenotype and function.
- T cells contribute to or regulate inflammatory responses in adipose tissue, influencing metabolic dysfunction.
- Fat-associated lymphoid clusters (FALCs) support immune surveillance against pathogens and antigens.
Outlook:
- Understanding species-specific (mouse vs. human) and depot-specific differences in adipose tissue immunity and metabolism is critical.
- Sex-based differences in adipose tissue immunity and metabolism require further investigation.
- Addressing mechanistic questions is essential for advancing knowledge of adipose tissue immunity and its implications for diseases like cancer metastasis.
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