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The natural polyphenol fisetin in atherosclerosis prevention: a mechanistic review

Wei Yu1,2,3, Yaping Zhao4, Iqra Ilyas4

  • 1School of Materials Science and Engineering, Hefei University of Technology, Hefei, Anhui, 230009, China.

The Journal of Pharmacy and Pharmacology
|May 11, 2024
PubMed

Insights

Fisetin, a natural polyphenol, shows promise in combating atherosclerotic cardiovascular disease (ASCVD). Research indicates its protective effects on blood vessels and cells, suggesting potential as a future therapy for atherosclerosis.

Area of Science:

  • Cardiovascular Research
  • Pharmacology
  • Natural Product Chemistry

Background:

  • Atherosclerotic cardiovascular disease (ASCVD) incidence and mortality are rising globally.
  • Fisetin, a natural polyphenol, has emerged as a compound with potential anti-atherosclerotic properties.

Purpose of the Study:

  • To review the pharmacologic actions of fisetin in experimental atherosclerosis.
  • To evaluate fisetin's protective effects on key cardiovascular cell types.

Main Methods:

  • Literature review of studies on fisetin and experimental atherosclerosis.
  • Analysis of fisetin's effects on endothelial cells, macrophages, vascular smooth muscle cells, and platelets.

Main Results:

  • Fisetin demonstrates significant anti-atherosclerotic effects in experimental models.
  • Fisetin exhibits protective actions on various cardiovascular cell types relevant to atherosclerosis.

Conclusions:

  • Fisetin possesses profound cardiovascular actions with potential for clinical translation.
  • Further large-scale randomized clinical trials are needed to confirm fisetin's safety and efficacy in ASCVD patients.
Keywords:
atherosclerosiscardiovascular diseaseendothelial cellfisetinmacrophageplateletvascular smooth muscle cell

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