Safety and Efficacy of Biopsy in Patients with Diffuse Intrinsic Pontine Gliomas
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View abstract on PubMed
Summary
This summary is machine-generated.Stereotactic biopsies for diffuse intrinsic pontine gliomas (DIPGs) demonstrate high diagnostic yield and safety. This procedure offers valuable insights into molecular pathobiology for potential targeted therapies in aggressive brain tumors.
Area Of Science
- Neuro-oncology
- Pediatric oncology
- Neurosurgery
Background
- Diffuse intrinsic pontine gliomas (DIPGs) are aggressive brain tumors with a poor prognosis.
- Imaging is often diagnostic, but biopsies offer molecular insights for targeted therapy.
- Stereotactic biopsy is explored for diagnostic yield and safety in DIPGs.
Purpose Of The Study
- To determine the diagnostic efficacy of stereotactic biopsies in patients with diffuse intrinsic pontine gliomas.
- To evaluate the safety and complication rates associated with stereotactic biopsies in DIPG patients.
Main Methods
- Prospective observational study at a single tertiary care center.
- Inclusion of patients with clinical and radiological DIPG diagnosis undergoing biopsy (July 2018-June 2023).
- Utilized stereotactic frame-based, frameless, or endoscopic biopsy techniques.
Main Results
- 76 biopsies performed in 74 patients (40 children, 34 adults).
- Histopathological diagnosis of diffuse midline gliomas, H3K27M altered, was most common (85% pediatric, 55.9% adults).
- Diagnostic efficacy was 94.7% with a 10.8% complication rate; no permanent deficits or mortality.
Conclusions
- Stereotactic biopsy is a safe procedure for DIPGs with high diagnostic yield.
- Establishing safety may encourage wider adoption, improving disease understanding.
- Overcoming obstacles like brainstem eloquence is key for broader application.
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