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Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients

Genetic ancestry, proportion of African ancestry, and apolipoprotein L1 risk variants in kidney recipients

Zhongyang Zhang ¹, Zeguo Sun ¹, Peter Heeger ², Madhav C Menon ³

Zhongyang Zhang ¹, Zeguo Sun ¹, Peter Heeger ²

¹Department of Genetics and Genomic Sciences and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
²Division of Nephrology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
³Division of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut, USA.

⁰Department of Genetics and Genomic Sciences and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons +

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May 11, 2024

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Summary

No abstract available on PubMed

Keywords:

APOL1 genetic ancestry

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Genome-wide Association Studies-GWAS

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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