Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The JAK-STAT Signaling Pathway

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Efficacy and Safety of Tocilizumab in Rheumatoid Arthritis Patients in the Middle East: Real-world Data.

Current rheumatology reviews·2026

Same author

Fatal Cardiomyopathy Secondary to Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report.

The American journal of case reports·2026

Same author

Correlation between Self-Perceived Voice Handicap and Symptoms of Autonomic Nervous System in Patients with Fibromyalgia Syndrome: A Questionnaire-based Observational Study.

Journal of voice : official journal of the Voice Foundation·2026

Same author

Cardiovascular Risk Factors and Antiphospholipid Antibodies in Giant Cell Arteritis-Related Thrombosis.

Archives of rheumatology·2026

Same author

Avascular necrosis in antiphospholipid syndrome: pathophysiology, risk factors, and management.

Clinical rheumatology·2025

Same author

Managing Yao Syndrome: A Case of Beneficial Treatment with Upadacitinib and Leflunomide.

Mediterranean journal of rheumatology·2025

Same journal

Molecular Mechanisms of Diffuse Large B-Cell Lymphoma and the Complexities of Tumor Development.

Saudi medical journal·2026

Same journal

Polysomnographic and Clinical Characteristics of Narcolepsy in Saudi Arabia: <i>A 12-Year Retrospective Study</i>.

Saudi medical journal·2026

Same journal

Etiology, Management, and Outcomes of Hospitalized Heart Failure Patients: <i>A Single-Center Study</i>.

Saudi medical journal·2026

Same journal

Effect of Anesthetic Agents on Middle Ear Pressure: Systematic Review and Meta-Analysis.

Saudi medical journal·2026

Same journal

Evaluation of Raqeem Health Information System in Primary Healthcare Centers in Makkah, Saudi Arabia, Using the DeLone and McLean Information System Success Model.

Saudi medical journal·2026

Same journal

Integrating Traditional and Complementary Medicine into Saudi Primary Care: <i>A Literature Review in Light of the WHO 2025-2034 Strategy</i>.

Saudi medical journal·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 26, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

Rheumatology research in Arab countries

Ali S M Jawad¹, Georges El Hasbani², Imad Uthman²

¹Department of Rheumatology, The Royal London Hospital, Bancroft Road, London, United Kingdom.

Saudi Medical Journal

|May 11, 2024

Summary

No abstract available in PubMed .

More Related Videos

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025

Related Experiment Videos

Last Updated: Jun 26, 2025

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis

Published on: October 6, 2023

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

Published on: June 6, 2025