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Development of a kidney microphysiological system hardware platform for microgravity studies.

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A new Kidney Chip Perfusion Platform (KCPP) enables studying microgravity

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Area of Science:

  • Space biology
  • Renal physiology
  • Biomedical engineering

Background:

  • Current methods for assessing kidney function in microgravity lack sensitivity.
  • Existing "organ on chip" models are incompatible with spaceflight constraints.
  • Early kidney dysfunction detection is crucial for astronaut health.

Purpose of the Study:

  • To develop and validate a spaceflight-compatible hardware platform for kidney microphysiological models.
  • To enable the study of kidney proximal tubule function under microgravity conditions.
  • To facilitate early detection of kidney dysfunction in space.

Main Methods:

  • Engineering of the Kidney Chip Perfusion Platform (KCPP) with key components: kidney microphysiological system (MPS), housing, valve block, media/fixative cassettes, and precision syringe pump.
  • Deployment of the KCPP on two International Space Station National Laboratory (ISSNL) missions (CRS-17 and CRS-22).
  • Collection of proximal tubule microphysiological system (PT-MPS) effluent for biomarker and transcriptomics analysis.

Main Results:

  • The KCPP successfully supported kidney MPS experiments in microgravity.
  • Effluent recovery for biomarker analysis was achieved.
  • RNA suitable for transcriptomics analysis was successfully recovered, demonstrating system functionality.

Conclusions:

  • The Kidney Chip Perfusion Platform (KCPP) is a viable, semi-autonomous hardware solution for kidney research in microgravity.
  • The KCPP enables sensitive assessment of kidney function and dysfunction mechanisms in space.
  • This technology advances the study of renal physiology and disease in the space environment.