Overall and metastasis-free survival of Afro-Caribbean patients with biochemical recurrence after radical...

Area of Science:

• Oncology
• Urology
• Radiotherapy

Background:

• Salvage radiotherapy is standard for biochemical recurrence post-prostatectomy.
• Some patients do not benefit from early salvage radiotherapy (OBS) or only receive it late (LSR).
• Limited data exists, especially for high-risk populations like men of African descent.

Purpose of the Study:

• To evaluate metastasis-free survival (MFS) and overall survival (OS) in patients not receiving early salvage radiotherapy.
• To identify risk factors for disease progression in this cohort.
• To compare outcomes between OBS and LSR groups.

Main Methods:

• Retrospective, single-center study of 154 patients treated with radical prostatectomy.
• Patients were categorized into OBS (no salvage radiotherapy) and LSR (late salvage radiotherapy) groups.
• Median follow-up was 10.0 years (OBS) and 11.8 years (LSR).

Main Results:

• MFS was similar between OBS (90.6% at 10 years) and LSR (93.3% at 10 years) groups.
• Median MFS was approximately 19.7 years for both groups.
• OS was significantly higher in the OBS group (95.9% at 10 years) compared to the LSR group (76.1% at 10 years).

Conclusions:

• Patients not receiving early salvage radiotherapy demonstrated favorable MFS and OS.
• The study highlights the need for improved risk stratification using molecular and genomic markers.
• Personalized medicine approaches are crucial for optimizing treatment decisions in prostate cancer recurrence.