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Related Concept Videos

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors01:19

Oral Hypoglycemic Agents: α-Glucosidase Inhibitors

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α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
Acarbose and miglitol are...
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Glucose Transporters01:27

Glucose Transporters

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Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
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Related Experiment Video

Updated: Jun 26, 2025

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
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Exogenous Glucose Interferes with Antimicrobial-Mediated ROS Accumulation and Bacterial Death.

Weiwei Zhu1, Lisheng Xiao1, Shouqiang Hong1

  • 1State Key Laboratory of Vaccines for Infectious Diseases, Xiang-An Biomedicine Laboratory & State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Department of Laboratory Medicine, School of Public Health, Xiamen University, 4221-117 South Xiang-An Road, Xiang-An District, Xiamen, Fujian Province 361102, China.

ACS Infectious Diseases
|May 12, 2024
PubMed
Summary

Glucose in IV fluids can reduce antibiotic effectiveness against bacteria, a phenomenon known as glucose-mediated antimicrobial tolerance. This occurs by suppressing bacterial killing, not growth, and can be reversed by specific metabolites.

Area of Science:

  • Microbiology
  • Pharmacology
  • Biochemistry

Background:

  • Glucose is a common component in intravenous fluid formulations, often used with antimicrobial drugs.
  • The impact of glucose on antimicrobial efficacy, particularly bactericidal activity, remains incompletely understood.
Keywords:
antimicrobial-mediated killingfructose-1,6-bisphosphateglucosereactive oxygen species (ROS)sodium citratesodium pyruvate

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