Risk factors associated with ototoxicity in long-term nasopharyngeal carcinoma survivors
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Ototoxicity is the most frequent patient-reported outcome in long-term nasopharyngeal carcinoma survivors treated with intensity-modulated radiotherapy. Age 50+, diabetes, and specific radiation doses are key risk factors for severe ototoxicity.
Area Of Science
- Oncology
- Radiotherapy
- Patient-Reported Outcomes
Background
- Nasopharyngeal carcinoma (NPC) survivors often experience long-term side effects.
- Understanding patient-reported outcomes (PROs) is crucial for improving quality of life.
- Intensity-modulated radiotherapy (IMRT) is a standard treatment for NPC.
Purpose Of The Study
- To investigate patient-reported outcomes in long-term nasopharyngeal carcinoma survivors.
- To identify risk factors associated with common symptoms, particularly ototoxicity.
- To inform better treatment and symptom management strategies.
Main Methods
- Retrospective study of 223 NPC patients treated with radical IMRT (June 2009-June 2016).
- Analysis of disease status and patient-reported outcomes via follow-up.
- Otoxicity grading using the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0.
Main Results
- Ototoxicity was the most common PRO, affecting 52.9% of patients.
- Independent risk factors for grade 3-4 ototoxicity included age ≥ 50 years, diabetes, D2 dose ≥ 69 Gy, and V35 dose ≥ 91.5%.
- Grade 3-4 ototoxicity correlated with increased risk of other symptoms like dysgeusia, tongue dysfunction, hoarseness, dysphagia, and ocular toxicity.
Conclusions
- Ototoxicity is the predominant PRO in long-term NPC survivors treated with IMRT.
- Age, diabetes, and specific radiation dose parameters (D2 and V35) are significant risk factors for severe ototoxicity.
- These findings aid in targeted management and risk stratification for NPC patients.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
Related Concept Videos
Chronic pharyngitis refers to persistent inflammation of the pharyngial mucosa.
Etiology
It often arises from persistent viral or bacterial infections affecting sinuses and tonsils.
Additional contributing factors include inadequate dental hygiene, mouth breathing, recurring tonsillitis, allergic rhinitis, laryngopharyngeal reflux, and exposure to smoke, chemicals, and other environmental pollutants. Allergic reactions to pollen, mold, and pet dander, chronic cough, excessive voice usage,...
Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
Suction machine with adjustable pressure settings
Sterile suction catheters (appropriate size for the patient)
Sterile gloves
Sterile saline or water (for irrigation or lubrication)
Water-soluble lubricant
Personal protective...