Clinical evidence for the prognostic impact of metformin in cancer patients treated with immune checkpoint inhibitors
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View abstract on PubMed
Summary
This summary is machine-generated.Metformin use in cancer patients receiving immune checkpoint inhibitors (ICIs) was evaluated. The study found metformin associated with poorer overall survival, suggesting it may not improve, and could worsen, prognoses in this patient group.
Area Of Science
- Oncology
- Pharmacology
- Immunotherapy
Background
- Preclinical data suggested metformin could enhance immune checkpoint inhibitor (ICI) efficacy.
- Potential influence of metformin on cancer patient prognoses during ICI therapy was noted.
- Clinical evidence regarding metformin's role in ICI treatment outcomes was lacking.
Purpose Of The Study
- To evaluate the prognostic significance of metformin in cancer patients undergoing ICI therapy.
- To provide evidence-based insights for clinical practice regarding metformin and ICIs.
Main Methods
- Comprehensive literature search of electronic databases up to November 20th, 2023.
- Meta-analysis using Stata 17.0 to determine pooled hazard ratios (HRs) and 95% confidence intervals (CIs).
- Assessment of overall survival (OS) and progression-free survival (PFS).
Main Results
- 22 studies with 9,011 patients were included.
- Metformin use correlated with poorer OS (HR, 1.13; P=0.004) but not significantly with PFS (HR, 1.04; P=0.345).
- Subgroup analysis showed metformin significantly associated with adverse prognoses in Europeans (OS: HR, 1.23; P=0.001; PFS: HR, 1.14; P=0.024).
Conclusions
- Concomitant metformin use does not appear to improve prognostic outcomes in cancer patients on ICIs.
- Metformin may potentially correlate with inferior prognoses in this setting.
- Further research is needed to fully understand metformin's impact within ICI therapy.
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