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Revisiting Hypertension Treatment in Patients With Chronic Kidney Disease

Mario Funes Hernandez1, Tara I Chang1

  • 1Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, CA.

Seminars in Nephrology
|May 12, 2024
PubMed

Insights

Hypertension control is declining in chronic kidney disease (CKD) patients, necessitating new treatments. Novel therapies are emerging to improve blood pressure management in this high-risk population.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Hypertension is a leading cause of death and disability globally.
  • Hypertension control and awareness are decreasing in patients with chronic kidney disease (CKD).
  • CKD patients face severe hypertension management challenges and poorer outcomes.

Purpose of the Study:

  • To review novel therapeutics for improving blood pressure control in CKD patients.
  • To discuss challenges and advancements in managing hypertension in advanced CKD.
  • To highlight emerging tools for blood pressure management in this vulnerable population.

Main Methods:

  • Review of current literature on hypertension in CKD.
  • Discussion of established and novel pharmacological agents.
  • Exploration of emerging interventional strategies for blood pressure management.

Main Results:

  • Renin-angiotensin-aldosterone system inhibitors remain central but require adaptation for advanced CKD.
  • Newer agents like aldosterone synthase inhibitors and endothelin receptor antagonists show promise.
  • Renal denervation is an emerging interventional option.

Conclusions:

  • The outlook for hypertension management in CKD is improving.
  • A broader range of therapeutic options is becoming available.
  • Deeper understanding of hypertension in CKD facilitates better patient outcomes.

Keywords:
CKDChronic kidney diseaseRAS inhibitorshigh blood pressurehypertensionnephrology

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