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Updated: Jun 26, 2025
Biomimetic Materials to Characterize Bacteria-host Interactions
Published on: November 16, 2015
Effect of a biomimetic pathogen adsorbing device on inflammatory biomarkers in COVID-19 patients
Jan Schmieszek1, Thomas Fuehner1,2, Isabelle Renger1
1Department of Respiratory, Sleep and Intensive Care Medicine, Siloah Hospital, Hannover, Germany.
Introduction:
The Seraph 100 Microbind Affinity blood filter eliminate bacteria, viruses, fungi and toxins from blood stream.
Methods:
This is a prospective multicenter observational biomarker trial in PCR-positive SARS-CoV-2 patients with acute respiratory failure. Biomarkers were sequentially tested at three time points.
Results:
Forty-two patients with SARS-CoV-2 detected by PCR with acute respiratory failure were included. When receiving hemoperfusion treatment, 27 (64%) patients were on mechanical ventilation, 41 (98%) patients were treated in the ICU. The 3-month survival was 52%. After one hemoperfusion treatment cycle, D-dimer (p = 0.014), hemoglobin (p = 0.003) and LDH (p = 0.001) concentrations were significantly reduced 4 days after treatment. From the multiplex assay IL-1b, CXCL8/ IL-8, IL-10, IL-13, IL-15, CCL11/Eotaxin, G-CSF, and CXCL10/IP-10 were significantly reduced 1 h after treatment, however not 4 days later.
Conclusion:
Hemoperfusion with Seraph 100 Microbind Affinity Filter in patients with severe COVID-19 can transiently reduce several inflammatory biomarkers in the blood.
