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Pluronic P123/DMSO Lyotropic Liquid Crystal for Incorporating Bioactive Substances for Topical Application.

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Lyotropic liquid crystals (LLCs) show promise for transdermal drug delivery. These Pluronic P123/DMSO systems effectively deliver ibuprofen, correlating phase behavior with release kinetics.

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Area of Science:

  • Materials Science
  • Pharmaceutical Sciences
  • Biophysics

Background:

  • Lyotropic liquid crystals (LLCs) are increasingly explored for drug delivery due to their cell membrane-like structure.
  • LLCs offer controlled and selective drug release, making them suitable for transdermal applications.

Purpose of the Study:

  • To characterize binary (Pluronic P123/DMSO) and ternary (Pluronic P123/DMSO/Ibuprofen) LLCs for transdermal drug delivery.
  • To investigate the relationship between LLC properties and ibuprofen release kinetics.

Main Methods:

  • Characterization using liquid crystalline, thermal, and rheological analyses.
  • Infrared (IR) spectroscopy for intermolecular interactions.
  • In vitro release studies, atomic force microscopy (AFM), and contact angle measurements.

Main Results:

  • Defined concentration and temperature ranges for lyomesophase existence and determined phase transition enthalpies.
  • Identified correlations between LLC phase behavior, rheology, and ibuprofen release rates.
  • Evaluated surface morphology and adhesion of LLCs on a stratum corneum model.

Conclusions:

  • The characterized LLCs demonstrate potential as biocompatible transdermal delivery systems.
  • Understanding the interplay between LLC properties and drug release is crucial for optimizing delivery systems.