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Author Spotlight: Advancing Prostate Cancer Research Through Improved Tissue Sampling and Biobanking
Published on: November 17, 2023
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Incidental Prostatic Adenocarcinoma in Open Prostatectomy Specimens: An Institutional Experience
Sebastian Anebuokhae Omenai1, Oluwatobi Ayodeji Fashola2, Augustine O Takure2
1Department of Anatomical Pathology, Edo State University Uzairue, Nigeria.
Summary
Incidental prostate cancer was found in 5.7% of open prostatectomy specimens in Nigeria. Most detected cancers were well-differentiated, with no link to prostate weight. External consultations yielded more incidental cancer diagnoses.
Area of Science:
- Urology
- Pathology
- Oncology
Background:
- Prostatic diseases significantly impact African men's health.
- Open prostatectomy is common for benign prostate enlargement in Nigeria.
- Histopathological examination of removed prostates can reveal incidental prostate cancer.
Purpose of the Study:
- To determine the incidence of incidental prostate adenocarcinoma in open prostatectomy specimens.
- To analyze clinicopathological parameters associated with incidental prostate cancer.
- To investigate the relationship between prostate weight and incidental cancer diagnosis.
Main Methods:
- Retrospective review of 158 open prostatectomy specimens over 10 years (2009-2018).
- Detailed grossing and microscopic examination of all specimens.
- Statistical analysis of clinicopathological data using SPSS version 23.
Main Results:
- Incidental prostate adenocarcinoma detected in 5.7% of specimens.
- High-grade prostatic intraepithelial neoplasia (HGPIN) found in 1.9% of cases.
- Most incidental cancers (88.8%) occurred in patients aged 70-89; predominantly ISUP grade group one.
- Prostate weight did not correlate with incidental cancer diagnosis.
- External consultations yielded a higher rate of incidental cancer detection (72.7%) compared to in-hospital consultations.
Conclusions:
- The incidence of occult prostate cancer detected via open prostatectomy is relatively low.
- Prostate organ weight is not a predictor of incidental adenocarcinoma.
- Patients managed outside teaching hospitals showed a higher likelihood of incidental prostate cancer diagnosis.
