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Related Concept Videos

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Antihypertensive Drugs: Direct Renin Inhibitors01:25

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The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
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Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists01:18

Treatment for Pulmonary Arterial Hypertension: Endothelin Receptor Antagonists

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Endothelins (ETs) are potent vasoactive peptides critical in the human body's various physiological and pathological processes. One of the most promising therapeutic strategies for treating pulmonary arterial hypertension (PAH) involves counteracting the effects of these endothelins using a class of drugs known as endothelin receptor antagonists.
ETs are synthesized through a complex sequence of enzymatic steps, primarily involving an enzyme referred to as endothelin-converting enzyme...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers01:26

Treatment for Pulmonary Arterial Hypertension: Receptor Tyrosine Kinase Inhibitors and Calcium Channel Blockers

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Receptor tyrosine kinase inhibitors (TKIs) and calcium channel blockers (CCBs) are two critical categories of drugs employed in the treatment of pulmonary artery hypertension (PAH). PAH is a disease that causes high blood pressure in the pulmonary arteries, resulting in chest pain, fatigue, and shortness of breath.
TKIs, such as imatinib (Gleevec), are particularly effective in tackling the growth and mitogenic factors that become upregulated in PAH patients. These factors contribute to the...
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Antihypertensive Drugs: Action of β1 Blockers01:17

Antihypertensive Drugs: Action of β1 Blockers

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β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
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  11. Antihypertensive Medications And Risk Of Melanoma And Keratinocyte Carcinomas: A Systematic Review And Meta-analysis

Antihypertensive Medications and Risk of Melanoma and Keratinocyte Carcinomas: A Systematic Review and Meta-Analysis

Olivia G Cohen1, Matthew Taylor2, Cassandra Mohr3

  • 1Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

JID Innovations : Skin Science From Molecules to Population Health
|May 13, 2024

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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
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Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

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Quantification of Hypopigmentation Activity In Vitro
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Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues
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View abstract on PubMed

Summary
This summary is machine-generated.

Some blood pressure medications may increase skin cancer risk. This review found links between certain antihypertensives, like diuretics, and higher risks of basal cell carcinoma, squamous cell carcinoma, and melanoma.

Area of Science:

  • Dermatology and Pharmacology
  • Oncology
  • Epidemiology

Background:

  • Antihypertensive medications are widely prescribed, with some exhibiting photosensitizing properties.
  • Previous research on the association between antihypertensives and skin cancer risk has yielded inconsistent results.
  • The potential implications for skin cancer development require ongoing investigation as new evidence emerges.

Purpose of the Study:

  • To systematically review and meta-analyze the association between antihypertensive drug use and common skin cancers.
  • To evaluate dose-response relationships between specific antihypertensives and skin cancer incidence.
  • To clarify the link between photosensitizing medications and skin cancer risk.

Main Methods:

  • Systematic review and meta-analysis of 44 relevant studies.
Keywords:
Basal cell carcinomaEpidemiologyHealth services researchMelanoma

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  • Inclusion of studies reporting on cutaneous squamous cell carcinoma, basal cell carcinoma, and melanoma.
  • Analysis of dose-response relationships where data permitted.

    • Main Results:

    • Increased risk of basal cell carcinoma associated with calcium channel blockers, diuretics, and thiazides.
    • Elevated risk of squamous cell carcinoma linked to calcium channel blockers, diuretics, and thiazides.
    • Higher risk of melanoma observed with angiotensin-converting enzyme inhibitors, calcium channel blockers, and thiazides.
    • Evidence of dose-response relationships for several antihypertensive classes and skin cancer types.
    • Overall quality of evidence was rated as low to very low.

    Conclusions:

    • The meta-analysis suggests a potential causal association between certain antihypertensive medications, particularly diuretics, and an increased risk of skin cancer.
    • Further high-quality research is needed to confirm these findings and elucidate underlying mechanisms.
    • Patients on antihypertensives, especially those with photosensitizing properties, should be aware of potential skin cancer risks.
    Squamous cell carcinoma