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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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  11. The Value Of Chemokine And Chemokine Receptors In Diagnosis, Prognosis, And Immunotherapy Of Hepatocellular Carcinoma

The Value of Chemokine and Chemokine Receptors in Diagnosis, Prognosis, and Immunotherapy of Hepatocellular Carcinoma

Zhengyi Wu1, Liang Sun1, Yongkang Xu1

  • 1Hepatobiliary Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, People's Republic of China.

Cancer Management and Research
|May 13, 2024

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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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View abstract on PubMed

Summary
This summary is machine-generated.

Chemokine receptors (CCRs) influence liver cancer (HCC) progression and treatment response. A new CCRs-based model predicts HCC prognosis and identifies patients sensitive to sorafenib, offering new therapeutic strategies.

Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Chemokines and chemokine receptors (CCRs) play dual roles in anti-tumor and pro-tumor immunity.
  • CCRs impact tumor angiogenesis, metastasis, proliferation, invasiveness, and patient outcomes.

Purpose of the Study:

  • To identify differentially expressed CCRs in hepatocellular carcinoma (HCC).
  • To construct a prognostic gene signature based on CCRs for HCC.
  • To explore the role of CCRs in HCC treatment and prognosis.

Main Methods:

  • Extracted CCRs associated with HCC prognosis from TCGA and GEO databases.
  • Constructed and validated a prognostic gene signature using selected CCRs.
  • Performed functional experiments to investigate the role of CCR3 in HCC cells.
Keywords:
chemokinechemokine receptorshepatocellular carcinomaprognosis

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Main Results:

  • A prognostic model with five CCRs (CCL20, CCL23, CCR3, CCR10, CXCR3) was developed, with the risk score being an independent prognostic factor for HCC.
  • CCR3 expression correlated with poor HCC prognosis; interfering with CCR3 inhibited HCC cell proliferation and migration.
  • Risk scores were linked to drug sensitivity, with high-risk patients showing better sensitivity to sorafenib.

Conclusions:

  • A CCRs-related gene signature can improve HCC prognosis assessment and predict response to immunotherapy and tyrosine kinase inhibitors like sorafenib.
  • This signature offers potential new strategies for HCC diagnosis and treatment.
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