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Penicillamine-Induced Localised Cutis Laxa in a Patient with Wilson Disease: A Case Report

  • 02nd Department of Dermatology-Venereology, National Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Mediterranean Journal of Rheumatology +

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May 13, 2024

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May 13, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Penicillamine treatment for Wilson disease can cause localized cutis laxa (CL), a rare skin condition. This occurs due to potential inhibition of collagen fiber cross-linkage from long-term high-dose therapy.

Area Of Science

  • Dermatology
  • Medical Genetics
  • Pharmacology

Background

  • Wilson disease is a rare genetic disorder causing copper accumulation.
  • Penicillamine is a copper-chelating agent used to treat Wilson disease.
  • Penicillamine can induce various cutaneous reactions, including cutis laxa (CL).

Observation

  • A 41-year-old male with Wilson disease on long-term penicillamine therapy presented with a basal cell carcinoma.
  • Physical examination revealed diffuse, flaccid, and redundant skin on the right neck.
  • Histopathology confirmed findings consistent with localized cutis laxa.

Findings

  • Long-term, high-dose penicillamine treatment for Wilson disease can induce localized cutis laxa.
  • The mechanism may involve direct inhibition of collagen fiber cross-linkage.

Implications

  • Highlights a rare cutaneous side effect of penicillamine in Wilson disease patients.
  • Suggests careful monitoring for skin changes in patients undergoing long-term penicillamine therapy.
  • Underscores the importance of considering drug-induced conditions in dermatological diagnoses.

Keywords:

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