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The Important Role of Preoperative D-Dimer in Constrictive Pericarditis

Likui Fang1, Fangming Zhong1, Wenfeng Yu1

  • 1Department of Thoracic Surgery, Hangzhou Red Cross Hospital, Hangzhou, 310003, People's Republic of China.

Therapeutics and Clinical Risk Management
|May 13, 2024
PubMed

Insights

High preoperative D-dimer (DD) levels predict poor outcomes after pericardiectomy for constrictive pericarditis. Elevated DD indicates a higher risk of postoperative complications, including longer hospital and ICU stays.

Area of Science:

  • Cardiovascular Surgery
  • Hematology
  • Medical Diagnostics

Background:

  • Constrictive pericarditis requires surgical intervention (pericardiectomy).
  • Postoperative outcomes and complications following pericardiectomy are critical concerns.
  • The role of preoperative coagulation indicators in predicting these outcomes is not well-established.

Purpose of the Study:

  • To investigate the prognostic value of preoperative coagulation indicators.
  • To assess the predictive capability of D-dimer for postoperative complications in constrictive pericarditis patients.

Main Methods:

  • Retrospective analysis of 158 patients undergoing pericardiectomy.
  • Receiver Operating Characteristic (ROC) curve analysis to determine D-dimer cutoff values.
  • Comparison of postoperative outcomes between high and low D-dimer groups.
  • Logistic regression to identify independent risk factors.

Main Results:

  • Preoperative D-dimer (DD) effectively identified patients at risk for complications (AUC 0.771).
  • High DD levels correlated with increased need for vasoactive agents, longer intubation, ICU, chest drainage, and hospital stays.
  • High preoperative DD was an independent risk factor for postoperative complications (OR 6.892).

Conclusions:

  • Elevated preoperative D-dimer is significantly associated with adverse postoperative outcomes.
  • D-dimer serves as a valuable predictive marker for complications after pericardiectomy in constrictive pericarditis.
  • Preoperative D-dimer assessment can aid in risk stratification for these patients.
Abstract

Keywords:
D-dimerconstrictive pericarditisoutcomespostoperative complications

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