Effects of Repeated Doses of the Vero Cell Vaccine (SARS-Cov-2 Inactivated Vaccine) on Renal Functions in Balb/C Albino Mice
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View abstract on PubMed
Summary
This summary is machine-generated.This study found that the inactivated SARS-CoV-2 vaccine (Vero cells) showed no adverse effects on mice. Both single and repeated doses of the vaccine were safe for renal function and overall health.
Area Of Science
- Immunology
- Vaccinology
- Toxicology
Background
- Many COVID-19 vaccines received emergency use authorization before comprehensive safety and preclinical data were available.
- Preclinical safety assessments are crucial for understanding potential adverse effects of novel vaccines.
Purpose Of The Study
- To evaluate the impact of an inactivated SARS-CoV-2 vaccine (Vero cells) on the renal function and overall health of Balb/C Albino mice.
- To assess the safety profile of single and repeated doses of the Vero cell SARS-CoV-2 vaccine in a preclinical mouse model.
Main Methods
- Twenty-one BALB/c male mice were divided into three groups: control (saline), single vaccine dose, and double vaccine dose (14 days apart).
- Evaluated clinical status, feed/water consumption, body weight, urine/fecal output, and kidney histopathology.
- Serum and urinary markers of renal function (urea, creatinine, BUN) were analyzed.
Main Results
- No acute toxic symptoms or local injection site reactions were observed in vaccinated mice.
- No significant differences were found in feed consumption, water intake, body weight gain, or urine/fecal output between groups.
- Serum BUN, creatinine, urinary urea, and creatinine levels remained comparable across all groups.
- Histopathological examination of kidneys revealed no vaccine-induced abnormalities.
Conclusions
- Single or repeated intramuscular administration of the inactivated SARS-CoV-2 vaccine (Vero cells) is safe in BALB/c mice.
- The vaccine did not adversely affect the animals' clinical health, performance, or renal function in this preclinical study.
- Findings support the safety of this vaccine candidate in a preclinical setting.
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