Kimura's Disease in Unusual Anatomical Locations: Clinical and Radiological Characteristics

Area of Science:

• Rare diseases
• Dermatology
• Radiology

Background:

• Kimura disease (KD) is a rare condition.
• This study focuses on KD occurring in uncommon anatomical locations.

Purpose of the Study:

• To explore the clinical and imaging features of rare site Kimura disease (KD).

Main Methods:

• Retrospective analysis of five patients with rare site KD.
• Evaluation of clinical manifestations, laboratory results, and imaging features by two radiologists.

Main Results:

• Four patients had asymptomatic subcutaneous nodules in the upper arm or inguinal region; one had itching.
• Three patients had accompanying lymph node enlargement, and four had elevated eosinophils.
• Imaging revealed internal vascularity and enhancement in most lesions, with some showing edema.

Conclusions:

• Solitary or multiple subcutaneous nodules/masses in unusual sites suggest KD.
• Diagnosis is supported by lymphadenopathy, eosinophilia, and characteristic imaging findings of internal vascularity.