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Endometrium development patterns and BMI groups among in vitro fertilization patients; prognostic aspects
Viktor Vedelek1, Petra Bicskei2, Mariann Tábi2
1Department of Genetics, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Frontiers in Endocrinology
|May 13, 2024
Summary
Obesity impacts female fertility, but endometrial thickness is not strongly linked to IVF success. Higher body mass index (BMI) correlated with lower FSH and LH hormone levels.
Area of Science:
- Reproductive Endocrinology
- In Vitro Fertilization
- Obesity Medicine
Background:
- The rising prevalence of obesity presents challenges to female reproductive health and fertility treatments like in vitro fertilization (IVF).
- The relationship between endometrial thickness and IVF outcomes remains a subject of debate, necessitating further investigation.
Purpose of the Study:
- To investigate the association between body mass index (BMI), endometrial development, hormone levels, embryo quality, and clinical pregnancy rates in women undergoing IVF.
- To analyze anamnestic parameters and their correlation with IVF outcomes across different BMI categories.
Main Methods:
- A cohort of 537 women undergoing IVF/ICSI cycles was categorized into underweight, normal weight, overweight, and obesity groups based on BMI.
- Data collected included anthropometric measurements, stimulation characteristics, endometrial thickness, hormone levels (FSH, LH, AMH), embryo quality, and clinical pregnancy rates.
- A Support Vector Machine (SVM) model was developed to predict pregnancy outcomes using 22 variables.
Main Results:
- Pregnant women were significantly younger across underweight, normal weight, and overweight BMI categories.
- In the normal weight group, pregnant women had lower FSH and higher AMH levels.
- No significant differences in endometrial development were observed between pregnant and non-pregnant groups across BMI categories.
- A negative correlation was found between BMI and FSH/LH levels in the overall population.
- The SVM model achieved an average prediction accuracy of 61.71%.
Conclusions:
- Endometrial thickness does not appear to be strongly correlated with BMI in women undergoing IVF.
- FSH and LH levels show a decreasing trend with increasing BMI, suggesting a potential evolutionary role of nutritional status.
- While the developed SVM model shows promise, further optimization is required for reliable prediction of embryo transfer outcomes.
