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Pediatric Challenges With Cowden Syndrome and Graves' Disease: A Case Report
Saraladevi Manimaran1, Ramya Ramanathan1, Sundari Subramanian1
1Department of Pediatrics, Sree Balaji Medical College and Hospital, Chennai, IND.
Cureus
|May 13, 2024
Summary
Cowden syndrome, a PTEN gene disorder, increases cancer risk, particularly thyroid cancer. Managing Cowden syndrome with co-occurring Graves' disease in pediatric patients requires a multidisciplinary approach for optimal care.
Area of Science:
- Genetics
- Endocrinology
- Oncology
Background:
- Cowden syndrome is a rare genetic disorder caused by PTEN gene mutations.
- It presents with mucocutaneous lesions and a high risk of malignancies, especially thyroid cancer.
- Co-occurrence with thyroid disorders like Graves' disease complicates management.
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