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Improvement in Selective Serotonin Reuptake Inhibitor-Associated Sexual Dysfunction With Buspirone: Examining the
Kyra Lipman1, Holly Betterly1, Mousa Botros1
1Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Jackson Memorial Hospital, Miami, USA.
Cureus
|May 13, 2024
Summary
Selective serotonin reuptake inhibitor (SSRI) antidepressants can cause sexual dysfunction. Adding buspirone effectively treated delayed ejaculation in a patient taking sertraline, suggesting a potential treatment strategy.
Area of Science:
- Psychiatry
- Pharmacology
- Sexual Medicine
Background:
- Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed for depression.
- Sexual dysfunction is a frequent and distressing side effect of SSRIs, impacting treatment adherence.
- Identifying effective management strategies for SSRI-induced sexual dysfunction is crucial.
Observation:
- A patient experienced delayed ejaculation after starting sertraline.
- This sexual dysfunction resolved following the addition of buspirone to the treatment regimen.
Findings:
- Buspirone may be an effective treatment for selective serotonin reuptake inhibitor-induced sexual dysfunction, specifically delayed ejaculation.
- Case study and literature review support buspirone's potential role in managing SSRI-related sexual side effects.
Implications:
- Clinicians should consider buspirone as a therapeutic option for patients experiencing sexual dysfunction while on SSRIs.
- Further research is warranted to confirm the efficacy and safety of buspirone for SSRI-induced sexual dysfunction.
- Addressing sexual dysfunction can improve patient quality of life and medication adherence.
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