Decarboxylative Nucleophilic Fluorination of Aliphatic Carboxylic Acids
Qian Yu1, Donglin Zhou1, Junjun Ma1
1College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China.
Abstract:
Herein, we present a decarboxylative nucleophilic fluorination of carboxylic acids with a silver catalyst. This strategy enables the synthesis of a myriad of diverse and valuable fluorinated motifs under mild conditions, demonstrating good functional-group tolerance and utility in late-stage functionalization. In contrast to traditional electrophilic fluorination, this nucleophilic method utilizes a more readily available nucleophilic fluorinating reagent, providing substantial advantages in terms of cost efficiency, broad substrate scope, and functional-group compatibility.
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