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Renal function in diabetes mellitus.

A G Davies, D A Price, R J Postlethwaite

    Archives of Disease in Childhood
    |April 1, 1985
    PubMed
    Summary
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    Children with diabetes show abnormal kidney function. Overnight albumin excretion is a sensitive early indicator of renal damage in pediatric diabetes patients.

    Area of Science:

    • Pediatric Nephrology
    • Diabetology
    • Clinical Research

    Background:

    • Diabetes mellitus in children can lead to long-term complications affecting renal function.
    • Early detection of kidney damage is crucial for managing pediatric diabetes.
    • Assessing glomerular filtration rate, albuminuria, and blood pressure are key indicators.

    Purpose of the Study:

    • To evaluate renal function in children with diabetes mellitus.
    • To correlate renal parameters with glycaemic control, disease duration, and age.
    • To identify sensitive early markers for renal damage in this population.

    Main Methods:

    • Estimated glomerular filtration rate (GFR), day and night-time albumin excretion, and blood pressure were measured in 83 children with diabetes.

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  • Parameters were compared with glycaemic control (HbA1c, mean blood sugar, M value), age, and disease duration.
  • Normal values were established using age-matched controls.

    • Main Results:

    • GFR was elevated and correlated with disease duration.
    • Daytime albumin excretion correlated with disease duration and HbA1c.
    • Night-time albumin excretion was significantly elevated, correlating with disease duration, HbA1c, mean blood sugar, and M value.
    • Diastolic blood pressure was elevated but showed no correlation with other variables.

    Conclusions:

    • Abnormalities in renal function are confirmed in children attending a diabetic clinic.
    • Elevated night-time albumin excretion is a sensitive early indicator of renal damage in pediatric diabetes.
    • Monitoring overnight albumin excretion may aid in early detection and management of diabetic nephropathy in children.