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Related Experiment Video

Updated: Jun 26, 2025

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Whole-Brain 3D Activation and Functional Connectivity Mapping in Mice using Transcranial Functional Ultrasound Imaging

Published on: February 24, 2021

Comparing mouse and human cingulate cortex organization using functional connectivity.

Aran T B van Hout¹, Sabrina van Heukelum¹, Matthew F S Rushworth^2,3

¹Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, The Netherlands.

Brain Structure & Function

|May 13, 2024

Summary

This summary is machine-generated.

Comparative neuroimaging reveals similarities and differences in cingulate cortex organization between humans and mice. Understanding these brain connections aids in translating preclinical findings to human applications.

Keywords:

Cingulate cortex Comparative Frontal lobe Functional connectivity Mouse Translational neuroscience

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Last Updated: Jun 26, 2025

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Published on: February 24, 2021

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Modeling the Functional Network for Spatial Navigation in the Human Brain

Modeling the Functional Network for Spatial Navigation in the Human Brain

Published on: October 13, 2023

Area of Science:

Neuroscience
Comparative Anatomy
Brain Connectivity

Background:

The cingulate cortex is crucial for high-level behaviors and neuropsychiatric disorders.
Mouse models are used to study human brain functions, but human-mouse frontal cortex similarities are unclear.
Existing research offers conflicting views on mouse and human cingulate cortex resemblance.

Purpose of the Study:

To compare the connectivity and organization of the cingulate cortex in humans and mice using comparative neuroimaging.
To clarify the anatomical similarities and differences between human and mouse cingulate cortex.
To enhance the translational validity of preclinical research to human studies.

Main Methods:

Utilized comparative neuroimaging techniques to analyze cingulate cortex connectivity in both species.
Integrated mouse tracer data with comparable imaging data for cross-species analysis.
Examined anterior, midcingulate, and retrosplenial areas for organizational patterns.

Main Results:

Identified overall similarities in cingulate cortex organization between humans and mice, including anterior, midcingulate, and retrosplenial regions.
Discovered that the human cingulate cortex exhibits finer subarea organization than observed in mice.
Found that the human cingulate cortex has connections to prefrontal areas absent in the mouse brain.

Conclusions:

The study highlights both conserved and divergent organizational principles of the cingulate cortex across species.
Results provide a formal basis for understanding between-species brain organization.
Findings aim to improve the translation of preclinical findings to human neuroscience and therapeutics.