Possible sarcopenia and risk of chronic kidney disease: a four-year follow-up study and Mendelian randomization analysis
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View abstract on PubMed
Summary
This summary is machine-generated.Possible sarcopenia, a condition characterized by muscle loss, significantly increases the risk of developing chronic kidney disease (CKD). This study highlights sarcopenia as a potential predictor for early CKD detection and intervention strategies.
Area Of Science
- Gerontology
- Nephrology
- Public Health
Background
- Chronic kidney disease (CKD) is a known risk factor for sarcopenia, but the reverse association remains under investigation.
- Understanding the relationship between sarcopenia and CKD is crucial for developing preventative health strategies.
Purpose Of The Study
- To investigate the longitudinal and causal associations between possible sarcopenia and the risk of developing CKD.
- To determine if sarcopenia is an independent risk factor for CKD.
Main Methods
- Utilized data from the China Health and Retirement Longitudinal Study (CHIRLS) with over 7000 participants aged 40 and above.
- Employed binary logistic regression for cross-sectional and longitudinal analyses, and Mendelian Randomization (MR) to assess causality between appendicular lean mass (ALM) and CKD.
- Defined possible sarcopenia based on the Asian Working Group for Sarcopenia 2019 criteria and applied propensity score matching for robust analysis.
Main Results
- Cross-sectional analysis revealed that possible sarcopenia, low muscle strength, and low physical performance were significantly associated with prevalent CKD.
- Longitudinal follow-up indicated that possible sarcopenia and low physical performance increased the risk of incident CKD over four years.
- Mendelian Randomization analysis suggested that genetically predicted higher ALM was associated with a reduced risk of CKD.
Conclusions
- Possible sarcopenia is identified as an independent risk factor for both prevalent and incident chronic kidney disease.
- Sarcopenia shows potential as an early predictor for CKD, enabling timely identification and intervention.
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