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The many faces of sickle cell disease in children: complications in the appendicular skeleton

Marcela De La Hoz Polo1, Victoria E Hudson2, John Adu3

  • 1Everlight Radiology, London, UK.

Pediatric Radiology
|May 13, 2024
PubMed

Insights

Sickle cell disease (SCD) causes bone problems in children, including infections and bone death. This review helps radiologists identify these appendicular skeletal complications using imaging.

Area of Science:

  • Pediatric Radiology
  • Hematology
  • Orthopedics

Background:

  • Sickle cell disease (SCD) is an inherited red blood cell disorder.
  • Musculoskeletal complications are a major source of morbidity in children with SCD.
  • Common complications include osteomyelitis, osteoporosis, and osteonecrosis.

Purpose of the Study:

  • To familiarize pediatric radiologists with appendicular skeletal complications of SCD.
  • To describe the characteristic imaging appearances of these complications.

Main Methods:

  • Review of relevant literature and imaging findings in pediatric SCD patients.
  • Focus on appendicular skeletal manifestations.

Main Results:

  • Detailed description of imaging features for osteomyelitis, osteoporosis, and osteonecrosis in SCD.
  • Highlighting key diagnostic indicators for radiologists.

Conclusions:

  • Accurate imaging interpretation is crucial for managing SCD-related bone complications in children.
  • Radiologists play a vital role in the early diagnosis and management of these conditions.

Keywords:
Avascular necrosisComplicationInfectionMusculoskeletalOsteonecrosisSeptic arthritisSickle cell disease

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