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Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
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Antioxidant therapies for obstructive sleep apnea: A systematic review and meta-analysis

Tarun Krishna Boppana1, Saurabh Mittal2, Karan Madan1

  • 1Department of Pulmonary, Critical Care, and Sleep Medicine, All India Institute of Medical Sciences (AIIMS), Ansari Nagar, New Delhi, India, 110029.

Sleep & Breathing = Schlaf & Atmung
|May 13, 2024
PubMed
Abstract

Insights

Antioxidant therapy significantly improves endothelial function and sleep quality in obstructive sleep apnea (OSA) patients. This approach reduces oxidative stress without adverse effects, suggesting potential for future clinical use.

Area of Science:

  • Cardiovascular Medicine
  • Sleep Medicine
  • Pharmacology

Background:

  • Obstructive sleep apnea (OSA) is linked to cardiovascular issues driven by oxidative stress and sympathetic overactivity.
  • Targeting oxidative stress is a potential therapeutic strategy for OSA management.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy and safety of antioxidant therapies in patients with OSA.

Main Methods:

  • Searched PubMed and Embase for human studies on antioxidant therapies in OSA patients.
  • Included six studies (five RCTs, one case-control) with 160 OSA patients.

Main Results:

  • Antioxidants significantly improved flow-mediated dilatation (FMD) by 2.16% (95% CI 1.65-2.67).
  • Reduced malondialdehyde and increased glutathione levels, indicating decreased oxidative stress.
  • Improved Epworth sleepiness scale, oxygen desaturation index, and minimum oxygen saturation without adverse effects.

Conclusions:

  • Antioxidant therapy enhances endothelial function, reduces oxidative stress, and improves sleep parameters in OSA.
  • Further multicenter studies with longer follow-up are warranted to confirm the utility of antioxidant therapy for OSA.
Keywords:
AntioxidantFlow-mediated dilatationMeta-analysisN-acetyl cysteineOSA

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