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Cardiovascular outcomes for people hospitalised with COVID-19 in Australia, and the effect of vaccination:
Hari P Sritharan1,2, Kunwardeep S Bhatia3, William van Gaal4,5
1Royal North Shore Hospital, Sydney, NSW.
The Medical Journal of Australia
|May 14, 2024
Summary
This study found that while elevated troponin levels were common in hospitalized COVID-19 patients, clinical cardiovascular events were rare and unaffected by vaccination. However, COVID-19 vaccination significantly reduced the risk of in-hospital death and intubation.
Area of Science:
- Cardiology
- Infectious Diseases
- Public Health
Background:
- The cardiovascular impact of COVID-19 remains a significant concern.
- Understanding clinical outcomes and the role of vaccination is crucial for patient management.
Purpose of the Study:
- To determine the frequency of cardiovascular complications in hospitalized COVID-19 patients.
- To evaluate the effect of COVID-19 vaccination on these outcomes.
Main Methods:
- An observational cohort study was conducted using data from the Australian Cardiovascular COVID-19 Registry.
- Adults with laboratory-confirmed COVID-19 admitted to 21 hospitals between September 2020 and July 2022 were included.
- Key outcomes assessed included elevated troponin, arrhythmias, heart failure, cardiomyopathy, and pulmonary embolism.
Main Results:
- Of 1714 hospitalized patients, 10.6% died, and 17.4% required intensive care.
- Elevated troponin levels were observed in 37.4% of assessed patients, associated with higher mortality.
- While clinical cardiovascular events were infrequent and not influenced by vaccination, vaccination was linked to lower in-hospital death (aOR 0.38) and intubation (aOR 0.30) rates.
Conclusions:
- Elevated troponin is common in COVID-19 hospitalization, but significant clinical cardiovascular events are infrequent.
- COVID-19 vaccination does not appear to influence the likelihood of these cardiovascular events.
- Vaccination is associated with a reduced risk of severe outcomes like in-hospital death and intubation in COVID-19 patients.
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