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FISH for Pre-implantation Genetic Diagnosis
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[Fisher Syndrome].

Chieko Suzuki1

  • 1Department of Neurology, Hirosaki University Graduate School of medicine.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|May 14, 2024
PubMed
Summary

Fisher syndrome, a variant of Guillain-Barré syndrome, presents with ataxia, areflexia, and ophthalmoplegia. This immune-mediated neuropathy typically resolves well, often linked to preceding infections and anti-GQ1b antibodies.

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Fisher syndrome is an acute, immune-mediated neuropathy.
  • It is considered a variant of Guillain-Barré syndrome.
  • Characterized by a triad of ataxia, areflexia, and ophthalmoplegia.

Purpose of the Study:

  • To outline the clinical features and diagnostic markers of Fisher syndrome.
  • To discuss its subtypes and prognosis.

Main Methods:

  • Clinical case review and literature synthesis.
  • Analysis of diagnostic criteria and serological findings.

Main Results:

  • Fisher syndrome typically presents with ophthalmoplegia, ataxia, and areflexia.
  • Over 80% of patients test positive for anti-GQ1b antibodies.

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  • Subtypes include partial, Bickerstaff's brainstem encephalitis, and overlap with Guillain-Barré syndrome.

    • Conclusions:

    • Fisher syndrome is a distinct neurological entity with a generally favorable prognosis.
    • Antecedent infections and anti-GQ1b antibodies are key diagnostic indicators.
    • Understanding subtypes aids in accurate diagnosis and management.