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Genetically supported causality between gut microbiota and frailty: a two-sample Mendelian randomization study.

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  • 1Yangzhou University Medical College, Yangzhou, China.

Frontiers in Microbiology
|May 14, 2024
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Summary

This study used Mendelian randomization to investigate causality between gut bacteria and frailty. Certain gut bacteria are causally linked to frailty risk, offering new insights into its mechanisms.

Keywords:
Mendelian randomizationcausal associationfrailtygenome-wide association studygut microbiotaolder people

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Area of Science:

  • Microbiome research
  • Gerontology
  • Genetic epidemiology

Background:

  • Growing evidence links gut microbiota to frailty risk.
  • Causality between gut microbiota and frailty remains unclear.

Purpose of the Study:

  • To assess potential causal relationships between gut microbiota and frailty risk using Mendelian randomization (MR).

Main Methods:

  • Utilized genome-wide association study (GWAS) summary statistics for gut microbiome (N=18,340) and frailty (N=175,226).
  • Employed inverse variance weighted (IVW) method, weighted median, MR Egger regression, and MR-PRESSO.
  • Conducted reverse MR analysis to check for reverse causality.

Main Results:

  • Identified 7 bacterial taxa associated with frailty risk.
  • Class Bacteroidia and genus Eubacterium ruminantium group showed protective effects.
  • Class Betaproteobacteria, genus Allisonella, Bifidobacterium, Clostridium innocuum group, and Eubacterium coprostanoligenes group were associated with increased frailty risk.
  • No significant pleiotropy or heterogeneity detected.

Conclusions:

  • Mendelian randomization analysis supports a causal link between specific gut microbiota and frailty.
  • Findings provide novel insights into gut microbiota-mediated mechanisms of frailty.