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Circular RNA PRKCI (hsa_circ_0067934): a potential target in the pathogenesis of human malignancies

Shipei Qiu1, Kefan Zhang2, Siyu Chen3

  • 1Department of General Surgery, Southeast University Affiliated Zhongda Hospital, Nanjing, China.

Frontiers in Oncology
|May 14, 2024
PubMed

Insights

Circular RNAs (circRNAs), like circPRKCI, are stable molecules involved in cancer. This review details circPRKCI's role in tumor progression and identifies it as a potential anticancer target.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are endogenous non-coding RNAs with regulatory functions.
  • circPRKCI is upregulated in various tumors and linked to prognosis.
  • circRNAs play roles in gene regulation at transcriptional and post-transcriptional levels.

Purpose of the Study:

  • To review the biological functions of circRNA PRKCI in cancer.
  • To explore circPRKCI's mechanisms in tumorigenesis, progression, recurrence, and metastasis.
  • To identify circPRKCI as a potential molecular target for cancer therapy.

Main Methods:

  • Literature review of studies on circPRKCI and cancer.
  • Analysis of circPRKCI's involvement in signaling pathways (e.g., PI3K/AKT).
  • Investigation of circPRKCI's microRNA (miRNA) sponging activities.

Main Results:

  • circPRKCI is implicated in tumor initiation, growth, and spread.
  • circPRKCI activates oncogenic pathways like PI3K/AKT.
  • circPRKCI interacts with miRNAs, influencing gene expression in cancer.

Conclusions:

  • circPRKCI is a significant factor in various cancers.
  • Understanding circPRKCI's functions can lead to novel therapeutic strategies.
  • circPRKCI represents a promising target for developing new anticancer drugs.
Keywords:
CircPRKCIinvasionmalignant tumormigration and proliferationmolecular targetoverall survival

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