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Emerging roles of FOXK2 in cancers and metabolic disorders

Xiaoke Xing1, Xiangyong Que1, Sihao Zheng1

  • 1Cancer Center, Renmin Hospital of Wuhan University, Wuhan, China.

Frontiers in Oncology
|May 14, 2024
PubMed

Insights

Forkhead box K2 (FOXK2) influences cell functions and impacts various cancers. Its dual role as an oncogene or tumor suppressor offers potential for targeted cancer therapies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Genetics

Background:

  • The Forkhead box K2 (FOXK2) transcription factor is vital for cellular processes like proliferation, differentiation, and DNA repair.
  • FOXK2 exhibits context-dependent roles in cancer, acting as an oncogene in some cancers and a tumor suppressor in others.

Purpose of the Study:

  • To review recent advancements in understanding FOXK2 regulation and its downstream targets.
  • To highlight the role of FOXK2 dysregulation in cancer development.
  • To explore the therapeutic potential of targeting FOXK2 in cancer treatment.

Main Methods:

  • Literature review of recent studies on FOXK2.
  • Analysis of FOXK2's regulatory mechanisms and downstream targets.
  • Examination of FOXK2's role in various cancer types.

Main Results:

  • FOXK2 is involved in critical cellular functions including nucleotide biosynthesis and response to DNA damage.
  • FOXK2 acts as an oncogene in colorectal and liver cancers but as a tumor suppressor in breast, cervical, and non-small cell lung cancers (NSCLC).
  • Dysregulation of FOXK2 significantly impacts cancer etiology.

Conclusions:

  • Understanding FOXK2's complex roles is crucial for cancer research.
  • Targeting FOXK2 presents a promising avenue for novel cancer therapies.
  • Further research into FOXK2 regulatory networks and therapeutic strategies is warranted.
Keywords:
FOXK2cancerchemotherapy resistancede novo nucleotide synthesismetabolic disorderspost-translational modifications

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