KI mediated one-pot cascade reaction for synthesis of 1,3,4-selenadiazoles
Kumaresh Datta1, Bijeta Mitra1, Gyan Chandra Pariyar2
1Department of Chemistry, University of North Bengal Darjeeling West Bengal India pizy12@yahoo.com +91 0353 2699001 +91 0353 2776381.
Abstract:
An efficient catalytic system consisting of KI and K2S2O8 for a one-pot pseudo three-component cascade reaction in the preparation of a diverse array of 1,3,4-selenadiazole derivatives from easily accessible precursors aldehydes, hydrazine and elemental selenium is demonstrated in this paper. Here, KI is used as the surrogate of iodine and K2S2O8 as the oxidant. The key advantages of this protocol include an easy reaction set up, operational simplicity, high functional group tolerance and utilisation of low toxicity chemicals. Further, a radical quenching reaction was also performed to confirm the mechanistic pathway.
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