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Risk prediction of advanced colorectal neoplasia among diabetic patients: A derivation and validation study

  • 0The Jockey Club School of Public Health and Primary Care, Faculty of Medicine Chinese University of Hong Kong Hong Kong SAR China.
Jgh Open : an Open Access Journal of Gastroenterology and Hepatology +

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May 14, 2024

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May 14, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

A new clinical scoring system helps predict advanced colorectal neoplasia (ACN) in diabetic patients. This tool identifies high-risk individuals, guiding decisions for colonoscopy evaluations and improving cancer screening.

Area Of Science

  • Oncology
  • Gastroenterology
  • Preventive Medicine

Background

  • Colorectal cancer (CRC) is a significant global health concern.
  • Diabetic patients represent a population requiring targeted screening strategies.
  • Advanced colorectal neoplasia (ACN) necessitates effective risk stratification for timely intervention.

Purpose Of The Study

  • To develop and validate a clinical scoring system for predicting ACN risk.
  • To guide colonoscopy evaluation decisions in diabetic patients.
  • To identify independent risk factors for ACN in this cohort.

Main Methods

  • Utilized a large Chinese population database of diabetic patients undergoing colonoscopies (2008-2018).
  • Employed binary logistic regression analysis to identify independent risk factors for ACN.
  • Devised a risk score based on adjusted odds ratios (aORs) and validated it in an independent cohort.

Main Results

  • The ACN prevalence was 2.0% in both derivation and validation cohorts.
  • The risk score effectively stratified patients into average-risk (AR) and high-risk (HR) groups.
  • High-risk individuals demonstrated a 2.78-fold increased prevalence of ACN compared to average-risk individuals, with a concordance statistic of 0.70.

Conclusions

  • A clinical risk scoring system incorporating age, gender, smoking, hypertension, and aspirin use was developed.
  • This scoring system demonstrates utility in predicting ACN risk among diabetic patients.
  • The validated risk score aids in stratifying individuals who would benefit from colonoscopy.

Keywords:

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