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Research Domains Biomedical and Clinical Sciences Oncology and Carcinogenesis Predictive and prognostic markers
Research Domains
Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Human epididymis protein 4, a novel potential biomarker for diagnostic and prognosis monitoring of lung cancer

Human epididymis protein 4, a novel potential biomarker for diagnostic and prognosis monitoring of lung cancer

Tingting Zhang ¹, Lanhe Chu ², Wenchong Tan ³, Cuiping Ye ², Hangming Dong ²

Tingting Zhang ¹, Lanhe Chu ², Wenchong Tan ³

¹Infection Management Department of Zengcheng Campus, Nanfang Hospital, Southern Medical University, Guangzhou, China.
²Department of Respiratory and Critical Care Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
³Department of Teaching and Research, The Tenth Affiliated Hospital, Southern Medical University, Dongguan, China.

⁰Infection Management Department of Zengcheng Campus, Nanfang Hospital, Southern Medical University, Guangzhou, China.

The Clinical Respiratory Journal +

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May 14, 2024

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May 14, 2024

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View abstract on PubMed

Summary

This summary is machine-generated.

Human epididymis protein 4 (HE4) shows promise as a novel biomarker for lung cancer diagnosis and prognosis. Elevated serum HE4 levels are significantly higher in lung cancer patients, aiding in early detection and assessment of disease progression.

Area Of Science

Oncology
Biomarker Discovery
Molecular Diagnostics

Background

Lung cancer remains a leading cause of cancer-related mortality worldwide.
Accurate diagnostic and prognostic biomarkers are crucial for effective lung cancer management.
Human epididymis protein 4 (HE4), also known as WFDC2, is increasingly investigated for its potential role in various cancers.

Purpose Of The Study

To evaluate the diagnostic and prognostic value of serum HE4 in lung cancer.
To compare HE4's diagnostic efficacy against existing biomarkers.
To investigate HE4 expression in lung cancer tissues and cell lines.

Main Methods

Analysis of WFDC2 gene expression in lung cancer tissues using TCGA and UALCAN databases.
Quantification of serum HE4 levels in 160 individuals (lung cancer, benign lesions, healthy controls) via electro-chemiluminescent immunoassay.
Immunohistochemistry (IHC) and Western Blot (WB) to assess HE4 expression in tissues and cell lines.

Main Results

WFDC2 gene expression was significantly upregulated in lung cancer tissues.
Serum HE4 levels were markedly higher in lung cancer patients compared to controls and benign lesion groups (p < 0.001).
HE4 demonstrated superior diagnostic efficacy for lung cancer, particularly lung adenocarcinoma (AUC = 0.826), and correlated positively with poor prognosis.

Conclusions

Serum HE4 is a promising novel biomarker for the diagnosis of lung cancer.
HE4 can be utilized for assessing the prognosis of lung cancer patients.
Further research into HE4's clinical application in lung cancer is warranted.

Keywords:

diagnosis human epididymis protein 4 lung adenocarcinoma lung cancer prognosis

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