FERREG: ferroptosis-based regulation of disease occurrence, progression and therapeutic response

Area of Science:

• Biochemistry and Molecular Biology
• Cell Biology
• Genetics

Background:

• Ferroptosis is an iron-dependent cell death pathway implicated in diseases like cancer and neurodegeneration.
• Its regulation involves key pathways: system Xc-/GPX4 axis, lipid peroxidation, and iron metabolism.
• Understanding ferroptosis mechanisms is crucial for developing new therapeutic strategies.

Purpose of the Study:

• To introduce FERREG, a novel database for ferroptosis-related information.
• To consolidate data on ferroptosis regulation, disease association, and drug responses.
• To provide a comprehensive resource for researchers investigating ferroptosis.

Main Methods:

• Systematic literature review and data mining.
• Integration of data from existing biological databases.
• Curation of information on ferroptosis targets, regulators, drugs, and disease associations.

Main Results:

• The FERREG database contains 51 targets, 718 regulators, 445 drugs, and 158 disease responses related to ferroptosis.
• It explicitly describes molecular mechanisms and references data through cross-linking.
• FERREG provides a centralized platform for accessing ferroptosis-related knowledge.

Conclusions:

• FERREG serves as a valuable, comprehensive resource for the ferroptosis research community.
• The database facilitates understanding of ferroptosis's role in disease and drug development.
• It supports the exploration of novel therapeutic interventions targeting ferroptosis.