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Cyclin D1 expression in penile cancer
Wesliany Everton Duarte1,2, Jaqueline Diniz Pinho3,4, Syomara Pereira da Costa Melo1,5
1Postgraduate Program in Adult Health, Federal University of Maranhão, Maranhão, Brazil.
Oncotarget
|May 14, 2024
Summary
Cyclin D1 expression in penile cancer (PC) correlates with aggressive features and Human Papillomavirus (HPV) status. Its absence is linked to HPV-positive subtypes, while presence indicates higher grade and poorer prognosis, suggesting potential as a biomarker.
Area of Science:
- Oncology
- Pathology
- Molecular Biology
Background:
- Penile cancer (PC) is a significant health concern, particularly in certain regions.
- Understanding the molecular mechanisms and biomarkers associated with PC progression is crucial for improved patient outcomes.
- Cyclin D1 is a cell cycle regulator implicated in various cancers.
Purpose of the Study:
- To analyze the expression profile of cyclin D1 in penile cancer (PC) patients.
- To determine correlations between cyclin D1 expression and clinical-histopathological features of PC.
- To investigate the potential of cyclin D1 as a prognostic biomarker for PC.
Main Methods:
- Retrospective study of 100 PC patients treated between 2013-2017.
- Analysis of clinical, epidemiological, and histopathological data.
- Detection of Human Papillomavirus (HPV) DNA using polymerase chain reaction (PCR).
- Assessment of cyclin D1 expression via immunohistochemical techniques.
Main Results:
- Absence of cyclin D1 expression was significantly associated with HPV-positive histological subtypes (p=0.001).
- Cyclin D1 expression correlated with high-grade tumors (p=0.014), specific histological subtypes (p=0.001), sarcomatoid transformation (p=0.04), and perineural invasion (p=0.023).
- Patients with cyclin D1 expression showed a trend towards lower disease-free survival, though not statistically significant.
Conclusions:
- Cyclin D1 expression is linked to aggressive pathological features in penile cancer.
- The absence of cyclin D1 is a marker for HPV-positive PC subtypes.
- Cyclin D1 may serve as a potential biomarker for predicting poorer prognosis in penile cancer patients.
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