Related Experiment Video

Updated: Jun 26, 2025

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
12:37

Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model

Published on: September 7, 2013

18.2K

Cyclic AMP-regulatory element-binding protein: a novel UV-targeted transcription factor in skin cancer

Julianne C Nayar1, Myriam Abboud2, Katie M Dixon3

  • 1School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, 2050, Camperdown, NSW, Australia.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
|May 14, 2024
PubMed

Insights

Targeting the cyclic AMP-regulatory element-binding protein (CREB) offers a promising alternative to kinase inhibitors for treating skin cancers, potentially overcoming drug resistance and serving as a diagnostic marker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Dermatology

Background:

  • Kinase inhibitors are common melanoma and non-melanoma cancer therapeutics.
  • Drug resistance limits the long-term efficacy of kinase inhibitors.
  • Transcription factors represent an alternative therapeutic strategy.

Purpose of the Study:

  • To explore the role of cyclic AMP-regulatory element-binding protein (CREB) in skin cancer.
  • To evaluate CREB as a potential prognostic and diagnostic marker for skin cancer.
  • To investigate CREB as a novel therapeutic target for skin cancer.

Main Methods:

  • Review of studies on CREB activation and its role in skin carcinogenesis.
  • Analysis of CREB's involvement in melanocytes and keratinocytes.
  • Examination of CREB expression in skin cancer tissues.

Main Results:

  • Cyclic AMP-regulatory element-binding protein (CREB) is overexpressed or overactivated in various cancers, including skin cancer.
  • Ultraviolet radiation (UVR), a primary cause of skin cancer, activates CREB in skin cells.
  • CREB activation is observed in established skin cancers.

Conclusions:

  • CREB plays a significant role in the development and progression of skin cancer.
  • CREB holds potential as a prognostic and diagnostic biomarker for skin cancer.
  • Targeting CREB presents a novel therapeutic avenue for skin cancer treatment.
Keywords:
Melanoma skin cancerNon-melanoma skin cancerUltraviolet radiationcAMP-regulatory element-binding protein (CREB)

More Related Videos

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

6.9K
Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA04:12

Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA

Published on: December 19, 2019

14.3K

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.1K
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
36.7K
Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
35.3K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
3.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K