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Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Gene-Environment Interactions01:20

Gene-Environment Interactions

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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Updated: Jun 26, 2025

The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
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Environment and systemic lupus erythematosus.

Chiara Cardelli1, Dina Zucchi1, Elena Elefante2

  • 1Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, and Department of Medical Biotechnologies, University of Siena, Italy.

Clinical and Experimental Rheumatology
|May 14, 2024
PubMed
Summary
This summary is machine-generated.

Environmental factors significantly impact systemic lupus erythematosus (SLE) development and activity. This review summarizes key data on how external triggers influence SLE incidence and disease progression in genetically susceptible individuals.

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Area of Science:

  • Immunology
  • Environmental Health
  • Rheumatology

Background:

  • Systemic lupus erythematosus (SLE) is a complex autoimmune disease.
  • Its pathogenesis involves intricate interactions of genetic, epigenetic, and environmental factors.
  • The precise role of environmental triggers in SLE development and progression remains incompletely understood.

Purpose of the Study:

  • To review the current understanding of environmental factors influencing SLE.
  • To explore the impact of environmental exposures on SLE incidence.
  • To assess the effect of environmental factors on disease activity and damage in diagnosed SLE patients.

Main Methods:

  • Comprehensive literature search on environmental factors and SLE.
  • Synthesis of data on epidemiological studies and clinical observations.
  • Analysis of the relationship between environmental triggers and SLE pathogenesis.

Main Results:

  • Environmental factors are implicated in initiating immunological dysfunction in SLE.
  • Specific environmental exposures are linked to increased SLE incidence.
  • Environmental influences affect disease activity and long-term damage in SLE patients.

Conclusions:

  • Environmental factors play a crucial role in the multifactorial etiology of SLE.
  • Understanding these triggers is vital for SLE prevention and management strategies.
  • Further research is needed to elucidate specific environmental impacts on SLE.