Hereditary angioedema: current therapeutic management and future approaches

Area of Science:

• Immunology
• Genetics
• Pharmacology

Background:

• Hereditary angioedema (HAE) is a rare genetic disorder.
• HAE attacks can be life-threatening due to asphyxiation and significantly impact quality of life.
• Past treatments for HAE were limited in efficacy and convenience.

Purpose of the Study:

• To review current and emerging therapeutic strategies for hereditary angioedema (HAE).
• To provide an overview of historical HAE treatments.
• To discuss first-line HAE therapies and future treatment avenues.

Main Methods:

• Literature review of HAE pathophysiology and management.
• Analysis of currently available and investigational HAE therapies.
• Synthesis of evidence-based guidelines for HAE management.

Main Results:

• Numerous novel HAE therapeutic options have emerged in the last two decades.
• Current HAE drugs are more effective, better tolerated, and offer convenient administration.
• Numerous innovative HAE treatments are currently under development.

Conclusions:

• HAE requires prompt treatment to prevent fatal outcomes.
• Advances in HAE therapy have led to new evidence-based management guidelines.
• The evolving therapeutic landscape holds promise for revolutionizing HAE management.