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MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
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Retinal Tear Following Low-Frequency Repetitive Transcranial Magnetic Stimulation for Obsessive-Compulsive Disorder.

Beyazit Garip1, Burcu Buzkan1, Suleyman Demir2

  • 1Gulhane Training and Research Hospital, Department of Psychiatry, Ankara, Turkey.

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Summary

Repetitive transcranial magnetic stimulation (rTMS) may cause retinal detachment. Patients undergoing rTMS, especially those with pre-existing risks, require ophthalmologist consultation and close monitoring for eye health.

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Area of Science:

  • Neuroscience
  • Ophthalmology

Background:

  • Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique.
  • The retina's connection to the brain makes its response to rTMS an area of investigation.

Purpose of the Study:

  • To investigate the potential effects of rTMS on retinal health.
  • To assess changes in the retina following rTMS treatment for obsessive-compulsive disorder.

Main Methods:

  • A patient received 20 sessions of rTMS targeting the bilateral supplementary motor area using a Magventure X100 device.
  • The treatment involved specific parameters including 1 Hz frequency and 1200 total pulses.
  • Informed consent was obtained prior to the procedure.

Main Results:

  • Obsessive-compulsive disorder symptom scores (YBOCS and BABS) significantly improved after 15 rTMS sessions.
  • Following the 15th session, the patient developed retinal detachment in the right eye.
  • Eye examination revealed retinal ruptures in the left eye.

Conclusions:

  • rTMS treatment was associated with the development of retinal detachment and ruptures.
  • Patients with risk factors for retinal detachment may need specialized care and monitoring during rTMS.
  • Consultation with an ophthalmologist before rTMS is crucial for at-risk individuals.