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Bridging the Bio-Electronic Interface with Biofabrication
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Delivering biochemicals with precision using bioelectronic devices enhanced with feedback control.

Giovanny Marquez1, Harika Dechiraju2, Prabhat Baniya2

  • 1Applied Mathematics, Baskin School of Engineering, University of California, Santa Cruz, CA, United States of America.

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|May 14, 2024
PubMed
Summary

Precision medicine uses bioelectronics for personalized drug delivery. A new adaptive controller effectively manages device saturation, improving treatment accuracy for precision medicine applications.

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Area of Science:

  • Bioelectronics
  • Precision Medicine
  • Control Systems Engineering

Background:

  • Precision medicine aims to tailor treatments based on individual patient variability.
  • Bioelectronic devices offer real-time sensing and actuation for dynamic treatment personalization.
  • Challenges in bioelectronic device implementation include performance variability and operational limitations like voltage saturation.

Purpose of the Study:

  • To develop and evaluate an enhanced controller for bioelectronic devices in precision medicine.
  • To address challenges of device performance variability and saturation in closed-loop drug delivery systems.
  • To demonstrate the controller's efficacy in precise therapeutic delivery, specifically Fluoxetine.

Main Methods:

  • Developed an enhanced sliding mode controller with saturation management capabilities.
  • Conducted in silico experiments using a mathematical model of a proton pump.
  • Performed in vitro experiments for controlled Fluoxetine delivery, comparing with PID and ML controllers.

Main Results:

  • The enhanced sliding mode controller demonstrated satisfactory control actions despite model uncertainties and saturation.
  • In vitro experiments showed consistent performance across various reference signals for Fluoxetine delivery.
  • The controller maintained current values near the reference with a relative error below 7% in all trials.

Conclusions:

  • The developed controller effectively addresses saturation and variability challenges in bioelectronic devices.
  • This controller offers reliable precision for drug delivery strategies in precision medicine.
  • The findings support the integration of advanced control systems for enhanced bioelectronic therapeutic applications.