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Related Experiment Video

Updated: Jun 26, 2025

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
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The lactate wasteland.

Wei Wong1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|May 14, 2024
PubMed
Summary

Lactate activates GPR81 in white fat, triggering cancer-associated cachexia. This finding links metabolic changes to severe cancer wasting, offering potential therapeutic targets.

Area of Science:

  • Metabolic pathways
  • Cancer biology
  • Endocrinology

Background:

  • Cancer-associated cachexia is a debilitating condition characterized by involuntary weight loss.
  • White adipose tissue plays a role in energy homeostasis and metabolic regulation.
  • G protein-coupled receptor 81 (GPR81) is a receptor activated by lactate.

Purpose of the Study:

  • To investigate the role of GPR81 activation by lactate in white adipose tissue.
  • To determine the link between GPR81 signaling and cancer-associated cachexia.

Main Methods:

  • In vivo and in vitro studies involving cancer models.
  • Analysis of GPR81 expression and activity in white adipose tissue.
  • Assessment of metabolic and physiological changes associated with cachexia.

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Related Experiment Videos

Last Updated: Jun 26, 2025

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Main Results:

  • Lactate-induced activation of GPR81 in white adipose tissue was observed.
  • This activation was found to promote key features of cancer-associated cachexia.
  • Specific molecular pathways linking GPR81 to metabolic dysfunction were identified.

Conclusions:

  • Activation of GPR81 by lactate in white adipose tissue is a significant driver of cancer-associated cachexia.
  • Targeting the lactate-GPR81 axis in adipose tissue may offer a novel therapeutic strategy for cachexia.