Effects of Hydrogen Inhalation on Neurological Function Indicators, Oxidative Stress Markers, and E-Cadherin Levels...

Area of Science:

• Neuroscience
• Oncology
• Biochemistry

Background:

• Glioma is a primary brain tumor with significant morbidity.
• Oxidative stress and altered cell adhesion molecules play roles in glioma progression.
• Novel therapeutic strategies are needed to improve outcomes for glioma patients.

Purpose of the Study:

• To evaluate the efficacy of hydrogen inhalation therapy as an adjunct treatment for glioma.
• To assess the impact of hydrogen therapy on nerve function and tumor progression markers.
• To investigate the modulation of oxidative stress and E-cadherin by hydrogen therapy.

Main Methods:

• A randomized controlled trial involving 100 glioma patients.
• Comparison between routine treatment and hydrogen inhalation plus routine treatment groups.
• Assessment of clinical outcomes, nerve function indexes (NIHSS, S100β, NSE, GFAP), oxidative stress markers (MDA, SOD, CAT), and E-cadherin levels pre- and post-treatment.

Main Results:

• Hydrogen inhalation group showed significantly better overall clinical effect (90% vs 72%, P=.022).
• Improved nerve function indicated by reduced NIHSS scores and lower levels of S100β, NSE, and GFAP in the hydrogen group.
• Reduced oxidative stress (lower MDA, higher SOD and CAT) and increased E-cadherin levels observed in the hydrogen group compared to the control group (P<.05 for all).

Conclusions:

• Hydrogen inhalation therapy significantly improves nerve function and reduces oxidative stress in glioma patients.
• The therapy increases E-cadherin levels, suggesting a role in modulating tumor progression.
• Hydrogen therapy holds potential as an effective complementary treatment for brain glioma.