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Application of the Estimand Framework to Anesthesia Trials

Anurika P De Silva1, Kate Leslie2, Sabine Braat3

  • 1Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia; Methods and Implementation Support for Clinical and Health (MISCH) research Hub, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia.

Anesthesiology
|May 14, 2024
PubMed
Summary

The estimand framework helps anesthesia trials precisely define treatment effects, addressing post-randomization events like medication changes or death. Clear estimand definition is vital for relevant and understandable clinical trial results.

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