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Related Experiment Video

Updated: Jun 26, 2025

Mimicking and Measuring Occlusal Erosive Tooth Wear with the "Rub&Roll" and Non-contact Profilometry
08:47

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Erosive Tooth Wear, Wine Intake, and Genetic Variation in COMT and MMP2.

Juliane Rolim de Lavôr1, Adriana Mendonça da Silva2, Jenny Bogstad Søvik3

  • 1Department of Pediatric Dentistry, School of Dentistry, University of Pernambuco, Recife, Brazil.

Caries Research
|May 14, 2024
PubMed
Summary

Genetic factors and wine consumption are linked to erosive tooth wear (ETW). Specific gene variants, like COMT rs6269, influence ETW risk, especially when combined with drinking wine.

Keywords:
Single-nucleotide variantTooth wearWine drinking

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Area of Science:

  • Genetics and Oral Health
  • Environmental Influences on Dental Health

Background:

  • Erosive tooth wear (ETW) is a growing concern, particularly among younger individuals.
  • Understanding the interplay of genetic predispositions and environmental triggers is crucial for ETW management.

Purpose of the Study:

  • To investigate the association between specific genetic variants (MMP2 and COMT) and different phenotypes of erosive tooth wear.
  • To explore the role of environmental factors, such as diet and behavior, in modulating the risk of ETW.

Main Methods:

  • Analysis of saliva samples, erosive wear, and caries experience in 747 adolescents (16-18 years old).
  • Genotyping for MMP2 rs9923304 and COMT rs6269 variants.
  • Logistic regression analysis incorporating dietary and behavioral data.

Main Results:

  • A significant association was found between the COMT rs6269 variant and ETW, both in mild and severe cases.
  • Wine consumption emerged as a key environmental factor, increasing ETW risk in individuals with specific MMP2 and COMT variants.
  • The GG genotype of COMT rs6269 correlated with varying caries experience in individuals with enamel-only versus dentin-involved ETW.

Conclusions:

  • Genetic factors play a role in the development of erosive tooth wear.
  • Gene-environment interactions, particularly with wine consumption, significantly influence ETW.
  • These findings highlight the importance of personalized risk assessment for ETW.