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The clinical significance of PD-1 expression in patients with bladder cancer without lymph node metastasis: a comparative study with drained lymph nodes and tumor tissues

  • 0Urology & Nephrology Center, Department of Urology, Zhejiang Provincial People's Hospital(Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
The International Journal of Neuroscience +

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May 14, 2024

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May 14, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Programmed cell death-1 (PD-1) is highly expressed in bladder cancer patients without lymph node metastasis, particularly in draining lymph nodes. This suggests PD-1's role in the tumor immune microenvironment and potential prognostic value for PD-1 targeted therapy.

Area Of Science

  • Oncology
  • Immunology
  • Urology

Background

  • Immunotherapy, particularly targeting programmed cell death-1 (PD-1), is increasingly vital in bladder cancer treatment.
  • Understanding PD-1 expression in early-stage bladder cancer without lymph node metastasis is crucial for optimizing therapeutic strategies.

Purpose Of The Study

  • To investigate the expression and clinical significance of PD-1 in bladder cancer patients without lymph node metastasis.
  • To compare PD-1 expression levels in tumor tissues versus draining lymph nodes.
  • To analyze the correlation between PD-1 expression and clinical parameters.

Main Methods

  • Flow cytometry was used to detect PD-1 expression on T cells.
  • The proportion of PD-1 positive T cells expressing IFN-γ and CD105a was quantified.
  • Statistical analysis was performed to correlate PD-1 expression with clinical parameters.

Main Results

  • PD-1 expression was significantly higher in draining lymph nodes compared to tumor tissues (P < 0.001).
  • PD-1 positive cells were most abundant within CD3+ T cells.
  • IFN-γ-positive PD-1+ T cells were significantly more prevalent in draining lymph nodes than in tumor tissues (P < 0.001).
  • PD-1 expression in lymph nodes correlated positively with pathological grade, tumor size, and stage.

Conclusions

  • High PD-1 expression in bladder cancer without lymph node metastasis, especially in draining lymph nodes, highlights its role in regulating the tumor immune microenvironment.
  • PD-1 expression levels show potential as a prognostic biomarker.
  • Findings support PD-1 targeted therapy but necessitate further prospective studies for validation.

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